Michael Levitt

Michael Levitt, FRS (Hebrew: מיכאל לויט‎‎; born 9 May 1947) is an American-British-Israeli biophysicist and a professor of structural biology at Stanford University, a position he has held since 1987. Levitt received the 2013 Nobel Prize in Chemistry, together with Martin Karplus and Arieh Warshel, for "the development of multiscale models for complex chemical systems".

Michael Levitt was born in Pretoria, South Africa, to a Jewish family from Plungė, Lithuania; his father was Lithuanian and his mother is of Czech descent. He attended Sunnyside Primary School and then Pretoria Boys High School between 1960 and 1962. The family moved to England when he was 15. Levitt spent 1963 studying applied mathematics at the University of Pretoria. He attended King's College London, graduating with a Bachelor of Science degree in Physics in 1967.

In 1967, he visited Israel for the first time. Together with his Israeli wife, Rina, a multimedia artist, he left to study at Cambridge, where his three children were born. In 1979, he returned to Israel and conducted research at the Weizmann Institute of Science in Rehovot, becoming an Israeli citizen in 1980. He served in the Israeli Defense Forces for six weeks in 1985. In 1986, he began teaching at Stanford, and since then has split his time between Israel and California.

Levitt was a PhD student in Computational Biology at Peterhouse, Cambridge, and was based at the Laboratory of Molecular Biology from 1968 to 1972, where he developed a computer program for studying the conformations of molecules that underpinned much of his later work. In 1967, he was sent on behalf of the Laboratory of Molecular Biology at the University of Cambridge, to Israel, to work at the Weizmann Institute of Science, with Professor Shneior Lifson and a student of his – Arieh Warshel, of the Technion in Haifa. They were using computer modelling to understand the behaviour of biological molecules.

He went on to gain a research fellowship at Gonville and Caius College, Cambridge.

From 1980 to 1987, he was Professor of Chemical Physics at Weizmann Institute of Science, Israel. Thereafter, he has served as Professor of Structural biology, at Stanford University, California.

• Royal Society Exchange Fellow, Weizmann Institute, Israel, 1967–68
• Staff Scientist, MRC Laboratory of Molecular Biology, Cambridge, 1973–80
• Professor of Chemical Physics, Weizmann Institute, 1980–87 (dept. chair 1980–83)
• Professor of Structural Biology, Stanford University, 1987–

• Levitt, Michael (1972). Conformation analysis of proteins (PhD thesis). University of Cambridge. 
• "Nobel Prize in Chemistry for Peterhouse alumnus". Retrieved 11 October 2013. 
• Computer chemists win Nobel prize By James Morgan and Jonathan Amos, BBC News, 9 October 2013

Levitt was one of the first researchers to conduct molecular dynamics simulations of DNA and proteins and developed the first software for this purpose. He is currently well known for developing approaches to predict macromolecular structures, having participated in many Critical Assessment of Techniques for Protein Structure Prediction (CASP) competitions, where he criticized molecular dynamics for inability to refine protein structures. He has also worked on simplified representations of protein structure for analyzing folding and packing and developing scoring systems for large-scale sequence-structure comparisons. He has mentored many successful scientists, including Mark Gerstein and Ram Samudrala. Cyrus Chothia was one of his colleagues.

Industrial collaboration

Levitt has served on the Scientific Advisory Boards of the following companies: Oplon Ltd, Cocrystal Discovery, StemRad, Ltd, and Cengent Therapeutics, Inc.

Levitt was elected an EMBO Member in 1983, Fellow of the Royal Society (FRS) in 2001, member of the National Academy of Sciences in 2002, and received the 2013 Nobel Prize in Chemistry, together with Martin Karplus and Arieh Warshel, "for the development of multiscale models for complex chemical systems". He received the DeLano Award for Computational Biosciences in 2014. He was made a Fellow of the International Society for Computational Biology in 2015.

Levitt holds American, British and Israeli citizenship (he is the 6th Israeli to win the Nobel Prize in Chemistry in under a decade). Levitt spends time every year in Israel, where his wife and children live.