Luís Castro

One year after retiring from professional football, Castro began working as a manager with his final club Águeda, where he would remain for two seasons. He went on to be in charge of lowly Mealhada [pt], Estarreja and Sanjoanense, before being appointed at Penafiel in the top tier in summer 2004 and guiding it to the eleventh position in his debut campaign, the highlight being a 1–0 home win against Benfica.

Following Penafiel's relegation in 2006, Castro left the club, joining Porto's youth academy and eventually coaching the reserves. On 5 March 2014, following the resignation of Paulo Fonseca at the helm of the main squad, he was put in interim charge until the end of the season.

Castro led Porto's reserves to the LigaPro title in 2015–16; they were the first B team to win the division and as such ineligible for promotion. He then managed three sides in the Portuguese top flight after leaving for Rio Ave in November 2016, going on to Chaves and Vitória de Guimarães. In May 2019, at the end of his only campaign at the Estádio D. Afonso Henriques, he secured for them fifth place and a spot in the UEFA Europa League at the expense of neighbours Moreirense.

On 12 June 2019, Castro signed a two-year contract at Shakhtar Donetsk as a replacement for compatriot Paulo Fonseca who left for Roma after winning three Ukrainian Premier League championships in a row. In his first season in Eastern Europe, the team's hopes of a sixth consecutive national cup were thwarted in the last 16 by Dynamo Kyiv, but they did win a fourth league title in a row and reached the semi-finals of the Europa League.

In the 2020–21 edition of the UEFA Champions League, Castro led Shakhtar to win twice over Real Madrid in the group stages, yet they eventually finished third in the group and dropped into the Europa League, where they were eliminated in the round of 16 by Fonseca's Roma. In April 2021, with the domestic title all but taken by their rivals Dynamo, he announced that he would leave at the end of the campaign. He ended his tenure on 9 May with a 1–0 win over Inhulets Petrove. In the Ukrainian Cup, they had a bye to the quarter-finals, where they lost 1–0 after extra time at second-tier Ahrobiznes Volochysk.

On 12 May 2021, Shakhtar announced that Castro would be leaving the club after two years in charge.

Castro agreed to a one-year contract with Al-Duhail of the Qatar Stars League on 10 August 2021. On 18 March 2022, immediately after having won the Emir Cup by defeating Al-Gharafa 5–1, he left by mutual consent.

On 25 March 2022, Castro was named head coach of Botafogo in the Brazilian Série A, on a two-year deal. A year later, during his debut campaign in the Campeonato Carioca, the team won the Taça Rio with a 7–3 aggregate win over Audax Rio de Janeiro.

Castro led his side to their best-ever Série A start in eight rounds, only behind Palmeiras' feat in the 2019 edition. On 30 June 2023, he left after accepting an offer from a foreign club.

On 6 July 2023, Castro was appointed at Al Nassr of the Saudi Pro League, replacing the dismissed Rudi Garcia. On 12 August, they conquered the Arab Club Champions Cup following a 2–1 victory against Al Hilal. He started the AFC Champions League campaign with a 2–0 win at Iran's Persepolis on 19 September. In spite of star player Cristiano Ronaldo leading the scoring charts with a league all-time best 35 goals, his side finished second to the same opposition, losing the final of the King's Cup against that very team following a penalty shootout.