Henry Mitchell may refer to:
Henry Mitchell (Irish judge) (died 1384), Irish judge of the fourteenth century
Henry Mitchell (U.S. politician) (1784–1856), American politician
Henry Mitchell (oceanographer) (1830–1902), American oceanographer, namesake of USC&GS Mitchell
Henry Mitchell (mill owner) (1824–1898), British woollen mill owner
Henry Mitchell (footballer) (1874–1943), Australian rules footballer
H. Lane Mitchell (Henry Lane Mitchell, 1895–1978), Public works commissioner in Shreveport, Louisiana, 1934 to 1968
Henry L. Mitchell (1831–1903), 16th Governor of Florida
Henry Mitchell (1835–?), American engraver both for the Bureau of Engraving and Printing and in private practice
Henry Mitchell (brewer), of Mitchells & Butlers Brewery
His son, Henry Mitchell Junior, known as Harry Mitchell (brewer)
Kent Mitchell (Henry Kent Mitchell II, born 1939), American rower and Olympic medalist
Henry Mitchell, a fictional character from the television series Charmed; see List of Charmed characters
Henry Mitchell, a fictional character, Dennis's father in the U.S. comic strip Dennis the Menace