Dane Jackson

The Buffalo Bills selected Jackson in the seventh round with the 239th overall pick in the 2020 NFL draft. Jackson signed a four-year, $3.376 million contract with the Bills on May 7, 2020. He was placed on the reserve/COVID-19 list by the team on July 30, but was activated a week later. He was waived on September 5, 2020, and signed to the practice squad the next day.

Following injuries to cornerbacks Levi Wallace and Josh Norman, Jackson was elevated to the active roster on October 13, 2020, and reverted to the practice squad after the game. He was elevated to the active roster on October 24 for the team's week 7 game against the New York Jets, and reverted to the practice squad after the game. Against the Jets, he finished with three tackles, two passes defensed, and one interception as the Bills won 18–10. He was elevated again on October 31, November 7, November 14, and January 2, 2021, for the team's weeks 8, 9, 10, and 17 games against the New England Patriots, Seattle Seahawks, Arizona Cardinals, and Miami Dolphins, and reverted to the practice squad after each game. He was elevated again on January 15 and 23 for the divisional playoff game and AFC Championship Game against the Baltimore Ravens and Kansas City Chiefs, and reverted to the practice squad again following each game. On January 26, 2021, Jackson signed a reserves/futures contract with the Bills.

Jackson suffered a neck injury during a Monday Night Football game versus the Tennessee Titans on September 19, 2022, after colliding with teammate Tremaine Edmunds as the two attempted to tackle an opposing player. He was removed from the field in an ambulance, but was released from the hospital the following day after it was determined he had avoided major damage to the neck and spinal cord.

On March 17, 2023, Jackson re-signed with the Bills on a one-year contract.

On March 13, 2024, Jackson signed with the Carolina Panthers. He was placed on injured reserve on August 27 to begin the season.