Sir Clipsby Crewe (1599 – June 1648) was an English politician who sat in the House of Commonsfrom 1624 to 1626.
Crewe was the elder son of Sir Ranulph Crewe, Lord Chief Justice of England,and his firstwife Julia Clipsby. He matriculated from St John's College, Cambridge at Easter 1616 and was admitted at Lincoln's Inn on 29 May 1619. He was of Crewe Hall and wasknighted on 18 June 1620.
In 1624, Crewe was elected Member of Parliament for Downton in Wiltshire. He was re-elected MP for Downton in 1625. In 1626 he was elected MP for Callington in Cornwall.
Crewe died at the age of 48.
Crewe married and had sons Ralph, who was an artist killed in Paris, and John. His granddaughter Anne Crewe eventually succeeded to the inheritance. She married John Offley of Madeley Old Manor, Staffordshire. Her great-grandson was raised to the peerage as Baron Crewe of Crewe in 1806. Crewe's brother John was also an MP in 1654.