Juniors
As a junior Malisse compiled a singles win/loss record of 66–18, reaching as high as No. 10 in the junior world singles rankings in 1997. He made the quarterfinals of Wimbledon in 1997, whilst his final junior tournament was winning Eddie Herr later that year.
1998–2008
Malisse turned professional in 1998.
His best performance in Grand Slam singles competition was at the 2002 Wimbledon championships, where he reached the semi-final, beating Galo Blanco, Vince Spadea, Yevgeny Kafelnikov and Britain's Greg Rusedski in five sets en route, as well as former champion Richard Krajicek. He eventually lost to runner-up David Nalbandian, again in five sets. Malisse and Olivier Rochus won the French Open doubles championship in 2004. He has won three ATP tour singles titles: Delray Beach in 2005 and 2007, and Chennai in 2007.
2009
After a difficult year, Malisse found himself with a world ranking of 205. In his first tournament of the year in Brisbane, he lost in the last qualifying round to American Bobby Reynolds. A week later, in Medibank International Sydney, he reached the main draw, but lost to Mario Ančić in the first round.
At the Australian Open, he first won his qualifying matches. In the first round of the main draw, he defeated Michaël Llodra. However, in the next round, he lost to Andy Roddick in four sets. In October, he won a Challenger tournament in Lyon, and this pushed him back into the world's top 100 for the first time in nearly two years.
2010
Malisse lost in the third round of Wimbledon to Sam Querrey in five sets.
2011
Xavier started the 2011 season by reaching the final of Chennai. In March, he won the doubles title in the Indian Wells Masters with Alexandr Dolgopolov of Ukraine. He reached the fourth round at Wimbledon, where he lost to Bernard Tomic.
2012
Xavier reached the fourth round of Wimbledon where he faced Roger Federer. Federer won the first two sets and went a break up in the third, but Malisse came back to win the third set and move 2-0 in the fourth. Federer subsequently won six out of the next seven games to win the match and went on to win the title.
Key | W | F | SF | QF | #R | RR | Q# | A | P | Z# | PO | G | F-S | SF-B | NMS | NH |
(W) Won tournament; reached (F) final, (SF) semifinal, (QF) quarterfinal; (#R) rounds 4, 3, 2, 1; competed at a (RR) round-robin stage; reached a (Q#) qualification round; (A) absent; played in a (Z#) Davis/Fed Cup Zonal Group (with number indication) or (PO) play-off; won a (G) gold, (F-S) silver or (SF-B) bronze Olympic medal; a (NMS) downgraded Masters Series/1000 tournament; or (NH) tournament not held.
To avoid confusion and double counting, these charts are updated either at the conclusion of a tournament, or when the player's participation in the tournament has ended.
Current till 2013 Wimbledon Championships.
| Tournament | 1998 | 1999 | 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 2007 | 2008 | 2009 | 2010 | 2011 | 2012 | 2013 | W–L |
| Grand Slam tournaments |
| Australian Open | A | A | A | A | 2R | 3R | 1R | 1R | 2R | 1R | 1R | 2R | 1R | 3R | 1R | 2R | 8–12 |
| French Open | A | 1R | A | 3R | 4R | 3R | 4R | 2R | 1R | A | A | A | 2R | 2R | 1R | 1R | 13–11 |
| Wimbledon | A | 1R | A | 2R | SF | 1R | 4R | 2R | 2R | A | 2R | 1R | 3R | 4R | 4R | 1R | 20–13 |
| US Open | A | 3R | 2R | 4R | 3R | 4R | 1R | 4R | 3R | 2R | Q1 | Q1 | 1R | 1R | 1R | 1R | 17–13 |
| Win–Loss | 0–0 | 2–3 | 1–1 | 6–3 | 11–4 | 7–4 | 6–4 | 5–4 | 4–4 | 1–2 | 1–2 | 1–2 | 3–4 | 6–4 | 3–4 | 1–4 | 58–49 |
| ATP Masters Series |
| Indian Wells Masters | A | 3R | A | A | 1R | 2R | 2R | 1R | 3R | A | 2R | A | A | 3R | 2R | 1R | 10–10 |
| Miami Masters | A | 1R | 2R | A | 1R | 2R | 3R | 2R | 2R | A | 3R | A | 1R | 2R | 2R | 3R | 10–12 |
| Monte Carlo Masters | A | A | A | A | 1R | 1R | 1R | 2R | 1R | A | 1R | A | A | 1R | A | 1R | 1–8 |
| Rome Masters | A | A | A | A | 3R | 1R | A | A | 2R | A | A | A | A | 2R | Q2 | 1R | 4–5 |
| Madrid Masters | A | A | A | A | 2R | A | 1R | A | 1R | A | A | A | A | 3R | A | 1R | 3–5 |
| Canada Masters | A | A | A | 1R | 1R | 1R | 1R | 3R | QF | A | A | A | 2R | A | A | A | 6–7 |
| Cincinnati Masters | A | 1R | A | 2R | 3R | 2R | 1R | 1R | 1R | A | A | A | A | 1R | A | A | 4–8 |
| Shanghai Masters | Not Masters Series | A | A | A | A | A | 0–0 |
| Paris Masters | A | A | A | 3R | 2R | A | 2R | 1R | 1R | A | A | A | 1R | A | A | A | 4–6 |
| Hamburg Masters | A | A | A | A | 1R | 2R | 1R | A | 1R | A | 1R | NMS | 1–5 |
| Win–Loss | 0–0 | 2–3 | 1–1 | 3–3 | 6–9 | 3–7 | 4–8 | 3–6 | 7–9 | 0–0 | 3–4 | 0–0 | 1–3 | 6–6 | 2–2 | 2–5 | 43–66 |
| Career Statistics |
| Titles–Finals | 0–1 | 0–1 | 0–0 | 0–2 | 0–0 | 0–0 | 0–2 | 1–1 | 0–2 | 2–2 | 0–0 | 0–0 | 0–0 | 0–1 | 0–0 | 0–0 | 3–12 |
| Year End Ranking | 161 | 145 | 127 | 33 | 25 | 55 | 48 | 47 | 37 | 112 | 162 | 94 | 60 | 49 | 47 | 135 | |