For another queen with the same name, see Tzihuacxochitzin II.
Tzihuacxochitzin I was a Queen consort of Azcapotzalco as a wife of the king Tezozomoc, who was very famous. She was a daughter of the noble dignitary called Huitzilaztatzin. She married Tezozomoc, and it is mentioned by Chimalpahin that they had ten children: Epcoatzin Icel Azcatl Itzpapalocihuatl Aculnahuacatl Tzaqualcatl Tlacochcuecihuatl Chichilocuili Maxtla Xaltemoctzin Xiuhcanahualtzin Quaquapitzahuac
Xaltemoctzin had a daughter called Tzihuacxochitzin, named after his mother. Tzihuacxochitzin was a grandmother of Tecollotzin, Tlacateotl, Matlalatzin and Huacaltzintli. It is possible that she was a mother of the queen Ayauhcihuatl, who was a mother of Aztec emperor Chimalpopoca.