Tom Chambers or Thomas Chambers may refer to:
Tom Chambers (actor) (born 1977), English actor
Tom Chambers (basketball) (born 1959), American basketball player
Tom Chambers (judge) (1943–2013), Associate Justice of the Washington State Supreme Court
Tom Chambers (politician) (born 1928), Alberta MLA
Tom Chambers (trade unionist) (1867–1926), British trade union leader
Thomas Chambers (Agent of Madras) (fl. 1658–1662), British administrator and factor of the British East India Company
Thomas Chambers, twin brother to fellow actor Munro Chambers
Thomas Chambers (English cricketer), English cricketer
Thomas Chambers (South African cricketer) (1931-2015), South African cricketer
Thomas Chambers (footballer) (fl. 1892–1897), Scottish international footballer
Thomas Chambers Hine (1814–1899), architect based in Nottingham