Matt Iseman

Matthew C. "Matt" Iseman (born January 22, 1971) is an American comedian, actor, and television host, who began his career as a physician.

Iseman was born in Denver, Colorado. The son of a pulmonologist, Iseman was raised in Denver and followed his father into a medical career, earning a B.S. with honors from Princeton University and an M.D. from Columbia University College of Physicians and Surgeons. He did his residency and internship in internal medicine at the University of Colorado Hospital in his home town of Denver, and later relocated to the Los Angeles area.

Iseman began doing stand-up comedy, with a routine based partly on his experiences as a doctor. He worked with the improvisational comedy troupe The Groundlings, and in 2002 became a full-time professional comedian. In addition to comedy club work, Iseman’s medical background has led to performing medical and health-related organizations. He has performed at USO shows in Afghanistan, South Korea, Bosnia, and Hungary.

He cites Brian Regan as a comedy inspiration. Iseman's comedy outside of humor about medicine and medical profession is mainly observational, and he generally avoids off-color material.

Iseman has hosted the game shows Scream Play on E! and Casino Night on GSN. He appears as a regular cast member on the home makeover show Clean House and its companion outtakes show, Clean House Comes Clean, both on the Style Network. Additionally, he has hosted 6 out of 7 seasons of American Ninja Warrior on the channel G4, and then on the NBC network, with only season 1 that he did not host at all. Iseman began working with American Ninja Warrior in 2010. He uses his athleticism and work as a comedian to add his style to the show with Akbar Gbaja-Biamila (former American professional football player), and Kristine Leahy (sideline correspondent).

He also has worked episodically in television shows including The Drew Carey Show, NCIS, and General Hospital. He has appeared on the syndicated MAD TV, Comedy Central's Premium Blend, Fox's The Best Damn Sports Show Period, and Fox News Channel's Red Eye w/ Greg Gutfeld. He was the narrator of "Dumbest Stuff On Wheels" on "SPEED". As of May 4, 2010, Iseman is the host of Sports Soup, a spin-off of E!'s The Soup, on Versus.

He is on the 8th season of The Celebrity Apprentice

Iseman was diagnosed with rheumatoid arthritis in 2002, at age 31. His disease is being treated successfully.

• The Drew Carey Show
• General Hospital
• Courting Alex
• NCIS: Naval Criminal Investigative Service
• P Lo's House
• Clean House
• Clean House Comes Clean
• Choke.Kick.Girl: The Series
• Clean House: Messiest Home in the Country
• Dumbest Stuff on Wheels
• American Ninja Warrior
• The Best Time Ever
• The New Celebrity Apprentice