Mark Lee may refer to:
Mark Lee (actor) (born 1958), Australian actor and director
Mark Lee (American author), American novelist, playwright and journalist
Mark Lee (American football) (born 1958), former NFL player
Mark Lee (Australian rules footballer) (born 1959), Australian rules footballer
Mark Lee (comedian) (born 1968), Singaporean comedian
Mark Lee (footballer) (born 1979), English footballer playing
Mark Lee (ice hockey) (born 1984), Canadian ice hockey player
Mark Lee (left-handed pitcher) (born 1964), former MLB pitcher 1988–95
Mark Lee (musician) (born 1973), American musician and guitarist
Mark Lee (right-handed pitcher) (born 1953), former MLB pitcher 1978–81
Mark Lee (rugby league) (born 1968), rugby league footballer
Mark Lee (sportscaster), Canadian sportscaster
Mark C. Lee (born 1952), American astronaut