Manuel N. Mamba (born August 19, 1958) is a Filipino politician. A member of the Liberal Party, he has been elected as a Member of the House of Representatives of the Philippines, representing the Third District of Cagayan. First elected in 1995, he was re-elected in 2001, 2004 and 2007. He was also a former Municipal Mayor of Tuao, Cagayan from 1988-1995.
A graduate of the University of Santo Tomas, Secretary Mamba is a physician by profession. He is currently the Presidential Legislative Liaison Officer, with Cabinet Rank and a member of the Cabinet. He is a son of the late Congressman Francisco K. Mamba and Mrs. Estela Novena Mamba. He is married to Attorney Mabel Villarica-Mamba, a member of the Board of Directors of the Philippine Charity Sweepstakes Office.