Introduction
Lin He (born 1975) is an associate professor of cell and developmental biology at the University of California, Berkeley, in the Department of Molecular and Cell Biology, where she leads a lab focusing on identifying non-coding RNA which may play a role in tumorigenesis and tumor maintenance.
Life and work
Lin He received a B.S. from Tsinghua University in Beijing, China in 1997 and a Ph.D. from Stanford Medical School in 2003, working with Gregory S. Barsh. She was a postdoctoral fellow at Cold Spring Harbor Laboratory from 2003 to 2007 with Greg Hannon before joining the faculty at the University of California, Berkeley in 2008.
He's research focuses on the role that non-coding microRNAs play in the development and maintenance of tumors. Specifically, she has found that miR-34, a specific microRNA family, plays an essential role in blocking tumor cells from replicating in lung cancers, among others. Her current research is focused on understanding the mechanism that miR-34 plays in tumor suppression. Her lab is also studying the miR-17/92 family. Differential expression of this microRNA cluster has been observed in B-cell lymphomas, suggesting that miR-17/92 members are potential human oncogenes. He's work has appeared in Nature, Nature Genetics, and Science.
Awards
Lin He received the prestigious MacArthur Fellowship in 2009; the same year he also received the TWAS Prize.