Johnny Sins

Sins's first pornographic endeavors were through Craigslist ads. Brazzers has described him as a "go-to guy" for the studio, having performed in over 1,000 of their scenes as of April 2019.

On June 10, 2015, Pornhub launched a crowdfunding campaign through Indiegogo to produce the first adult film in space. Sins and fellow actress Eva Lovia were slated to perform in the film. If the project were successfully funded, the two would have received six months of rigorous preparation for the launch, including zero gravity, velocity, and temperature training. Sins said, "It's beyond just doing it for the money, or the money shot for that matter. It's about making history." The campaign raised $236,086 over 60 days, failing to reach its goal of $3.4 million.

In early 2017, Sins and fellow porn star Kissa Sins launched their YouTube channel SinsTV, which chronicled their day-to-day lives and featured sex advice. Following their brief separation in 2019, Sins became the sole operator of the channel, which later focused on his reaction videos and vlogs; as of January 2024, the channel has gained over 2.1 million subscribers and more than 109 million views. A video of Sins trying out various Turkish snacks briefly became the top YouTube video in Turkey.

In 2018, Sins received the award for Most Popular Male Performer by Women at the annual Pornhub Awards, for which winners were determined by users' streaming data.

In 2020, Sins stopped making porn videos for large studios and focused on producing his own content, stating at the time that he may return to working for the large studios in the future. As of January 2024, he has performed as a pornographic actor in almost 3,000 videos.