Jeff Cease (born June 24, 1967) is an American musician, best known as the lead guitarist of the American blues-rock band The Black Crowes from 1989–1991. He appeared on their debut album Shake Your Money Maker. His last performance with the band was October 19, 1991 at Hammersmith Odeon in London.

Cease, who was born in Nashville, Tennessee, later formed the Nashville-based band Bitter Pills. In 2008 he was hired by American Idol participant Bucky Covington for his own band.

Cease also spent some time in Trent Tomlinson's band and currently plays with Eric Church.