Vice Admiral Henry Killigrew (c.1652 – 9 November 1712) was a Royal Navy officer and Member of Parliament.
He was the son of the playwright Henry Killigrew. He was active in the Royal Navy during 1670s and 1680s, and was promoted to vice-admiral in 1689, but was suspected of Jacobite sympathies and not given a sea command after 1693. He was however appointed a Lord of the Admiralty in that year.
He was Member of Parliament for Stockbridge from 1702 to 1705 and for St Albans from 1705 to 1708, initially as a member of the Parliament of England, and then (following the Acts of Union in 1707) as a member of the Parliament of Great Britain.
He married Lucy, the daughter of Thomas Jervoise of Herriard, Hampshire, with whom he had a son and 3 daughters.